According to the World Health Organization (WHO), over 2.3 million women were diagnosed with breast cancer in 2020, making it the most diagnosed cancer worldwide and the leading cause of cancer-related deaths among women (WHO, 2021). The incidence of breast cancer is rising by around 3% per year, with higher mortality rates observed in lower-income countries due to limited access to early screening and treatment. In wealthier nations, 1 in 12 women are diagnosed with breast cancer, whereas in lower-income countries, the rate is 1 in 27. More concerning is the disparity in mortality--1 in 48 women die from breast cancer in low-income countries compared to 1 in 71 in high-income countries (WHO, 2022). In sub-Saharan Africa, breast cancer now has the highest mortality rate among all cancers affecting women, surpassing cervical cancer.

The largest prostate cancer biopsy dataset – involving over 95,000 images – has been created by researchers in Sweden to ensure AI can be trained to diagnose and grade prostate cancer for real world clinical applications. The researchers will call today, at the European Association of Urology annual congress (EAU22), for large-scale clinical trials of artificial intelligence (AI) algorithms and greater global coordination to ensure that AI enhanced diagnostics, prognostication, and treatment selection can help save lives. There is a shortage of pathologists around the world, both generalists and those specialised in urology. AI can help in detecting prostate cancer at an early stage, but because of the vast differences in the way clinics prepare samples, scan images and in the diverse patient populations they serve, many algorithms do not have universal application. The team, from Karolinska Institutet, worked with colleagues from Radboud University Medical Center in the Netherlands, University of Turku in Finland and Google Health in the US to run an AI competition involving nearly 1,300 developers from around the world.

Renal transplantation is widely regarded as the best treatment for patients with end-stage kidney disease. Over the past 15 years, demand in the UK for kidney transplants has been rising, resulting in more elderly deceased donors being considered. The problem with elderly donors is that kidney function deteriorates with age. Kidney transplants from elderly donors are associated with higher risks of early failure. Early failure of a kidney graft is a disastrous outcome for the recipient.

Celiac Disease (CD) and Environmental Enteropathy (EE) are common causes of malnutrition and adversely impact normal childhood development. Both conditions require a tissue biopsy for diagnosis and a major challenge of interpreting clinical biopsy images to differentiate between these gastrointestinal diseases is striking histopathologic overlap between them. In the current study, we propose four diagnosis techniques for these diseases and address their limitations and advantages. First, the diagnosis between CD, EE, and Normal biopsies is considered, but the main challenge with this diagnosis technique is the staining problem. The dataset used in this research is collected from different centers with different staining standards. To solve this problem, we use color balancing in order to train our model with a varying range of colors. Random Multimodel Deep Learning (RMDL) architecture has been used as another approach to mitigate the effects of the staining problem. RMDL combines different architectures and structures of deep learning and the final output of the model is based on the majority vote. CD is a chronic autoimmune disease that affects the small intestine genetically predisposed children and adults. Typically, CD rapidly progress from Marsh I to IIIa. Marsh III is sub-divided into IIIa (partial villus atrophy), Marsh IIIb (subtotal villous atrophy), and Marsh IIIc (total villus atrophy) to explain the spectrum of villus atrophy along with crypt hypertrophy and increased intraepithelial lymphocytes. In the second part of this study, we proposed two ways for diagnosing different stages of CD. Finally, in the third part of this study, these two steps are combined as Hierarchical Medical Image Classification (HMIC) to have a model to diagnose the disease data hierarchically.

Celiac Disease (CD) is a chronic autoimmune disease that affects the small intestine in genetically predisposed children and adults. Gluten exposure triggers an inflammatory cascade which leads to compromised intestinal barrier function. If this enteropathy is unrecognized, this can lead to anemia, decreased bone density, and, in longstanding cases, intestinal cancer. The prevalence of the disorder is 1% in the United States. An intestinal (duodenal) biopsy is considered the "gold standard" for diagnosis. The mild CD might go unnoticed due to non-specific clinical symptoms or mild histologic features. In our current work, we trained a model based on deep residual networks to diagnose CD severity using a histological scoring system called the modified Marsh score. The proposed model was evaluated using an independent set of 120 whole slide images from 15 CD patients and achieved an AUC greater than 0.96 in all classes. These results demonstrate the diagnostic power of the proposed model for CD severity classification using histological images.

Machines use Google-type algorithms on biopsy images to help children get treatment faster. A study published in the open access journal JAMA Open Network today by scientists at the University of Virginia schools of Engineering and Medicine says machine learning algorithms applied to biopsy images can shorten the time for diagnosing and treating a gut disease that often causes permanent physical and cognitive damage in children from impoverished areas. In places where sanitation, potable water and food are scarce, there are high rates of children suffering from environmental enteric dysfunction, a disease that limits the gut's ability to absorb essential nutrients and can lead to stunted growth, impaired brain development and even death. The disease affects 20 percent of children under the age of 5 in low- and middle-income countries, such as Bangladesh, Zambia and Pakistan, but it also affects some children in rural Virginia. For Dr. Sana Syed, an assistant professor of pediatrics in the UVA School of Medicine, this project is an example of why she got into medicine.

Celiac Disease (CD) and Environmental Enteropathy (EE) are common causes of malnutrition and adversely impact normal childhood development. CD is an autoimmune disorder that is prevalent worldwide and is caused by an increased sensitivity to gluten. Gluten exposure destructs the small intestinal epithelial barrier, resulting in nutrient mal-absorption and childhood under-nutrition. EE also results in barrier dysfunction but is thought to be caused by an increased vulnerability to infections. EE has been implicated as the predominant cause of under-nutrition, oral vaccine failure, and impaired cognitive development in low-and-middle-income countries. Both conditions require a tissue biopsy for diagnosis, and a major challenge of interpreting clinical biopsy images to differentiate between these gastrointestinal diseases is striking histopathologic overlap between them. In the current study, we propose a convolutional neural network (CNN) to classify duodenal biopsy images from subjects with CD, EE, and healthy controls. We evaluated the performance of our proposed model using a large cohort containing 1000 biopsy images. Our evaluations show that the proposed model achieves an area under ROC of 0.99, 1.00, and 0.97 for CD, EE, and healthy controls, respectively. These results demonstrate the discriminative power of the proposed model in duodenal biopsies classification.

Here's one reason why artificial intelligence is definitely in our medical future: "A.I. don't get tired," Roberto Novoa, a dermatologist based at Stanford, said. "You can show them literally thousands or millions of images, and there's little additional cost to each one that's analyzed." That's huge for a profession that has long been criticized for its physicians, residents, nurses, and other support staff running on next to no sleep. Even with sleep, a human radiologist may analyze an image wrong: They might get fatigued after several hours, or be inclined to identify something as, say, a particular melanoma after having identified it several-hundred times over. The algorithm, on the other hand, will give you the same answer it would have given at any other time, whether it's 2:00 a.m. on Saturday or 3:00 p.m. on a Wednesday.

A Convolutional Neural Network was used to predict kidney function in patients with chronic kidney disease from high-resolution digital pathology scans of their kidney biopsies. Kidney biopsies were taken from participants of the NEPTUNE study, a longitudinal cohort study whose goal is to set up infrastructure for observing the evolution of 3 forms of idiopathic nephrotic syndrome, including developing predictors for progression of kidney disease. The knowledge of future kidney function is desirable as it can identify high-risk patients and influence treatment decisions, reducing the likelihood of irreversible kidney decline.